CL 82198
CL 82198
CAS: 307002-71-7
Molecular Formula: C17H22N2O3
CL 82198 - Names and Identifiers
CL 82198 - Physico-chemical Properties
| Molecular Formula | C17H22N2O3 |
| Molar Mass | 302.37 |
| Density | 1.159±0.06 g/cm3(Predicted) |
| Boling Point | 515.6±40.0 °C(Predicted) |
| Solubility | DMSO: >10mg/mL |
| Appearance | powder |
| Color | white to off-white |
| pKa | 14.19±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months. |
| In vitro study | CL-82198 (10 μM; 24 hours) significantly reduces LS174 cell migration. CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells. |
CL 82198 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
CL 82198 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.307 ml | 16.536 ml | 33.072 ml |
| 5 mM | 0.661 ml | 3.307 ml | 6.614 ml |
| 10 mM | 0.331 ml | 1.654 ml | 3.307 ml |
| 5 mM | 0.066 ml | 0.331 ml | 0.661 ml |
Last Update：2024-01-02 23:10:35
CL 82198 - Reference Information
| biological activity | CL-82198 is a selective MMP-13 inhibitor. CL-82198 binds to the entire S1 'pocket of MMP-13, which is the basis of its lack of inhibitory activity against MMP-13 selectivity and other MMPs. CL-82198 available for osteoarthritis (OA) research. |
| Animal Model: | 10-week-old C57BL/6J mice (performed MLI surgery) |
| Dosage: | 1, 5, 10 mg/kg body weight |
| Administration: | Intraperitoneal injection; every other day for 12 weeks |
| Result: | Prevented and decelerated MLI-induced osteoarthritis progression. |
Last Update：2024-04-09 21:21:28
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Spot supply
Product Name: CL 82198 Visit Supplier Webpage Request for quotationCAS: 307002-71-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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